کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5187154 1381122 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effectual drug-releasing porous scaffolds from 1,6-diisocyanatohexane-extended poly(1,4-butylene succinate) for bone tissue regeneration
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Effectual drug-releasing porous scaffolds from 1,6-diisocyanatohexane-extended poly(1,4-butylene succinate) for bone tissue regeneration
چکیده انگلیسی
Tooth extraction induces residual ridge resorption which impairs function and aesthetic of dental prostheses. This study aimed at developing new bone scaffolds to be used in a tooth socket for preserving bone mass from the residual ridge resorption. Scaffolds were fabricated from poly(1,4-butylene succinate) extended with 1,6-diisocyanatohexane (PBSu-DCH) by solvent casting and particulate leaching technique. Four different weight ratios of NaCl particles (200-400 μm; used as the porogen species) and the polymer were varied (i.e., 25, 30, 35, and 40% based on the weight of the polymer). Scaffolds were evaluated for their physical (i.e., morphology, porosity, pore volume, and pore size), physico-mechanical (i.e., mechanical properties and water retention ability), and biological properties (i.e., cytotoxicity and bone cell attachment). The potential for use of the as-prepared materials as effectual drug-releasing scaffolds for bone tissue regeneration was assessed by incorporating ipriflavone and studying the release of the drug from the drug-loaded scaffolds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 49, Issue 11, 27 May 2008, Pages 2678-2685
نویسندگان
, , , ,