کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5187485 | 1381131 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of new versatile functionalized polyesters for biomedical applications
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
A new family of branched polymers was synthesized for different biomedical applications such as the preparation of targeted nanoparticulate drug carriers. They are new copolymers of hydroxy-acids and allyl glycidyl ether. The functional groups (allyl-, hydroxyl- and carboxyl-) to which various groups will be grafted are linked to the polymer backbone. The resulting polymers were characterized by 1H NMR, 13C NMR, size exclusion chromatography (SEC), elemental analysis and differential scanning calorimetry (DSC). In vitro cytotoxicity assays were also conducted to ensure biocompatibility of the polymers. In order to obtain some structural evidences, different molecules have been grafted on the pendant groups. The method allows a rapid and easy synthesis of allyl-, hydroxyl- and carboxyl-branched degradable polymers for grafting various bioactive molecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 46, Issue 25, 28 November 2005, Pages 11263-11272
Journal: Polymer - Volume 46, Issue 25, 28 November 2005, Pages 11263-11272
نویسندگان
Véronique Nadeau, Grégoire Leclair, Shilpa Sant, Jean-Michel Rabanel, Richard Quesnel, Patrice Hildgen,