Theoretical study of temperature induced transition and hyper stability of collagen mimics

Collagen a polymer, is the nature's most abundant protein. It has an immense tensile strength and is the main constituent of ligaments, tendons, etc. The present communication interprets the experimental data of thermally induced transition in collagen mimics as reported by Steven K. Holmgren and co-workers. The theoretical transition curves as obtained by the modified Zimm and Bragg model are found to be in good agreement with the experimental data. The order of the values of nucleation parameter and enthalpy changes obtained theoretically, attributes the increase in the degree of the stability of collagen mimics [(Pro-Pro-Gly)10〈(Pro-Hyp-Gly)10〈(Pro-Flp-Gly)10].