کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5191925 1381243 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Properties of l-tyrosine based polyphosphates pertinent to potential biomaterial applications
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Properties of l-tyrosine based polyphosphates pertinent to potential biomaterial applications
چکیده انگلیسی
Since their introduction by Kohn and Langer et al. in 1984, l-tyrosine based 'pseudo' poly(amino acids) have undergone extensive research in the area of polymeric biomaterials. Starting from l-tyrosine based diphenolic monomers, polyiminocarbonates, polycarbonates and polyarylates have been developed by Kohn and co-workers and are being investigated for potential orthopedic biomaterial applications. Mao et al. have reported development of l-tyrosine based polyphosphates and polyphosphonates in a patent, however, detailed structural and physico-chemical characterization studies on such polymers have not been reported yet. For the purpose of the current paper, using a novel solid phase process for synthesis of l-tyrosine based diphenolic monomers and adapting the polymerization process described by Mao et al., l-tyrosine based polyphosphates were developed and investigated for their pertinent bioengineering properties. The properties investigated consist of chemical solubility, hydrophilicity and hydrolytic degradation. The results of this investigation are crucial to validate further investigation of biomaterial applications of these polymers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 46, Issue 7, 10 March 2005, Pages 2133-2140
نویسندگان
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