کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5200834 | 1502875 | 2017 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biodegradable chitosan-poly(Æ-caprolactone) dialdehyde copolymer networks for soft tissue engineering
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chitosan/PCL block-copolymer networks were synthesized using different amounts of aldehyde end-capped polycaprolactone as crosslinking agent. The crosslinking reaction was performed by dissolving both components in the common solvent hexafluoroisopropanol (HFIP). The formation of the network was confirmed by solubility tests in good solvents of both components. The resulting composition was determined by thermogravimetric analysis. The hydrophilic/hydrophobic networks behave as hydrogels; water sorption at pH7 is around 70% that of pure chitosan for a network containing 36% PCL blocks. The PCL domains were not able to crystallize, except for the CHT-64 sample as shown by DSC and X-ray diffraction. Enzymatic degradation of these networks is quite fast, thus, the network with 36% PCL presented a remaining weight of 22± 1% of their initial mass after 28 days of degradation in lipase. Nevertheless in purely hydrolytic degradation, the remaining weight was 86± 3% for the same time and composition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 138, April 2017, Pages 47-54
Journal: Polymer Degradation and Stability - Volume 138, April 2017, Pages 47-54
نویسندگان
M.A. Gámiz-González, A. Vidaurre, J.L. Gómez Ribelles,