کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5202738 1381908 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of ionizing radiation on physicochemical and biological properties of an amphiphilic macromolecule
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Impact of ionizing radiation on physicochemical and biological properties of an amphiphilic macromolecule
چکیده انگلیسی
An amphiphilic macromolecule (AM) was exposed to ionizing radiation (both electron beam and gamma) at doses of 25 kGy and 50 kGy to study the impact of these sterilization methods on the physicochemical properties and bioactivity of the AM. Proton nuclear magnetic resonance and gel permeation chromatography were used to determine the chemical structure and molecular weight, respectively. Size and zeta potential of the micelles formed from AMs in aqueous media were evaluated by dynamic light scattering. Bioactivity of irradiated AMs was evaluated by measuring inhibition of oxidized low-density lipoprotein uptake in macrophages. From these studies, no significant changes in the physicochemical properties or bioactivity were observed after the irradiation, demonstrating that the AMs can withstand typical radiation doses used to sterilize materials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 97, Issue 9, September 2012, Pages 1686-1689
نویسندگان
, , , , , , , ,