کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5203470 | 1381932 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro degradation of porous poly(l-lactide-co-glycolide)/β-tricalcium phosphate (PLGA/β-TCP) scaffolds under dynamic and static conditions
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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![عکس صفحه اول مقاله: In vitro degradation of porous poly(l-lactide-co-glycolide)/β-tricalcium phosphate (PLGA/β-TCP) scaffolds under dynamic and static conditions In vitro degradation of porous poly(l-lactide-co-glycolide)/β-tricalcium phosphate (PLGA/β-TCP) scaffolds under dynamic and static conditions](/preview/png/5203470.png)
چکیده انگلیسی
In vitro degradation of porous poly(l-lactide-co-glycolide)/β-tricalcium phosphate (PLGA/β-TCP) scaffolds was studied by incubating the samples in phosphate buffered saline (PBS) at 37 °C and pH 7.4 under dynamic loading with respect to static conditions for 12 weeks. Under dynamic conditions, acidity of PBS was alleviated by the better solution circulation, and water absorption of the scaffolds increased more than that under static conditions in the first 8 weeks. Changes in mass, height, diameter, relative molecular mass and its distribution also happened more remarkably under dynamic conditions. Moreover, obvious cracks and a larger amount of β-TCP particles were observed on the wall of the scaffolds after degradation for 12 weeks under dynamic loading. Compressive modulus and strength showed an increase from the beginning to the 10th week but were lower after then. Results showed that degradation of PLGA/β-TCP scaffolds under dynamic conditions exhibited a significantly faster rate than that under static conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 93, Issue 10, October 2008, Pages 1838-1845
Journal: Polymer Degradation and Stability - Volume 93, Issue 10, October 2008, Pages 1838-1845
نویسندگان
Yanfang Yang, Yunhui Zhao, Gongwen Tang, Hua Li, Xiaoyan Yuan, Yubo Fan,