کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5204055 1381947 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of porogen on the physico-chemical properties and degradation performance of PLGA scaffolds
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Effect of porogen on the physico-chemical properties and degradation performance of PLGA scaffolds
چکیده انگلیسی

The aim of the study was to examine the relationship between the structural features of PLGA 3-D scaffolds and their degradation performances. PLGA 3-D scaffolds were fabricated by solvent casting and particulate leaching using salt and sucrose particles as porogen and they were characterized in terms of structure, physico-chemical and mechanical properties. The in vitro degradation study was performed at 37 °C in PBS for 28 days and it included the determination of Mw, Mn, PI, water uptake, mass loss and pH changes of the degradation buffer. It was found that the preparation method scaffolds, in particular the choice of the porogen type and was responsible for the three-dimensional structure (pore size, porosity, apparent density and, mechanical properties) of the scaffold and for physico-chemical PLGA polymer modifications (polymer degradation reactions, polymer chain rearrangement, Tg changes). Scaffolds with high porosity (83.8-89.4%) and an interconnected network were obtained.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 95, Issue 4, April 2010, Pages 694-701
نویسندگان
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