کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5204127 1381950 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Degradation behaviors of star-shaped poly(ethylene glycol)-poly(ɛ-caprolactone) nanoparticles in aqueous solution
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Degradation behaviors of star-shaped poly(ethylene glycol)-poly(ɛ-caprolactone) nanoparticles in aqueous solution
چکیده انگلیسی

Star-shaped poly(ethylene glycol) (PEG)-poly(ɛ-caprolactone) (ɛ-PCL) block copolymers were synthesized via a ring-opening polymerization. Nanoparticles prepared by the precipitation/solvent evaporation technique exhibit a core-shell structure. The hydrolytic degradation of 3-arm PEG-PCL copolymeric nanoparticles was studied by dynamic light scattering (DLS), nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC). It was found that copolymers with shorter PCL block length degraded faster. The sizes of nanoparticles fluctuated during the initial degradation period, and then increased slightly before finally dropping off. The degradation mainly occurred at CL-CL linkages firstly then at the EO-CL linkages. The CL/EO molar ratios and the molecular weights of copolymers decreased as degradation time and a zero-order degradation behavior was observed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 92, Issue 10, October 2007, Pages 1891-1898
نویسندگان
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