کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5204558 | 1381965 | 2006 | 8 صفحه PDF | دانلود رایگان |
The tri-component copolymer poly(lactide-co-glycolide-co-caprolactone) (PLGC) was synthesized to prepare nanoparticles by the modified spontaneous emulsification solvent diffusion method (modified-SESD method); and the method was also modified by using the Tween60 instead of poly(vinyl alcohol) (PVA) as dispersing agent. The obtained nanoparticles have spherical shape and good particle distribution with mean size in the range from 100 to 200Â nm. The in vitro degradation behaviour of PLGC nanoparticles was investigated. It was found that PLGC nanoparticles could remain stable during the degradation with no agglomeration. Compared with PLA and PLGA nanoparticles, the degradation rate of PLGC nanoparticles is faster. After 9 weeks of hydrolysis, the Mn of PLGC is less by 10% of the original Mn. The mean radius of the nanoparticles increases from 68Â nm to 80Â nm continuously during the first stage, and after 4 weeks of degradation, the particles' size decreases gradually from 80Â nm to about 40Â nm. These results suggest that the PLGC nanoparticles may show degradation-controlled drug release behaviour and seem to be a promising drug delivery system.
Journal: Polymer Degradation and Stability - Volume 91, Issue 9, September 2006, Pages 1929-1936