کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5206341 | 1382305 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of an in vitro confinement test to predict the clinical handling of polymer-based injectable bone substitutes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development of an in vitro confinement test to predict the clinical handling of polymer-based injectable bone substitutes Development of an in vitro confinement test to predict the clinical handling of polymer-based injectable bone substitutes](/preview/png/5206341.png)
چکیده انگلیسی
The objective of the current study was to present a simple and standardized system as a preliminary attempt to assess the confinement of polymer-based injectable bone substitutes (IBSs) in vitro. Four different types of polymer-based IBSs were selected as model compounds, a thermosensitive collagen gel, a colloidal gelatin gel, a covalently crosslinked oligo(poly(ethylene glycol)fumarate (OPF) gel and a OPF-calcium phosphate composite. A ceramic-based IBS (i.e. a self-setting calcium phosphate cement) was used as reference. The confinement of all IBSs was tested under three different conditions: (1) no flow (as control), (2) dynamic flow after injection and (3) dynamic flow during injection. The results presented herein confirmed that the proposed test can be used to quantify the confinement of various IBSs within artificial defects under static or dynamic flow conditions, thereby offering a potential tool for predictive quantitative determination of the confinement of IBSs in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Testing - Volume 32, Issue 8, December 2013, Pages 1379-1384
Journal: Polymer Testing - Volume 32, Issue 8, December 2013, Pages 1379-1384
نویسندگان
Matilde Bongio, M. Reza Nejadnik, F. Kurtis Kasper, Antonios G. Mikos, John A. Jansen, Sander C.G. Leeuwenburgh, Jeroen J.J.P. van den Beucken,