کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5208745 | 1382604 | 2008 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecularly imprinted polymers with specific recognition for macromolecules and proteins
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecularly imprinted polymers with specific recognition for macromolecules and proteins Molecularly imprinted polymers with specific recognition for macromolecules and proteins](/preview/png/5208745.png)
چکیده انگلیسی
The hierarchical system of recognition in nature is based on interaction between the smallest elements in a matrix such as molecules and the cumulative interactions of larger parts such as the helices and sheets of proteins. The active sites of enzymes are composed of several amino acids, which bind the ligand molecules in a very specific way. However, the activity of the site is dependent on the stabilization of the three-dimensional structure by the interactions of hundreds of other residues. Likewise, a biomimetic polymeric network can be prepared by designing interactions between the building blocks of a biocompatible network and the desired specific analyte and stabilizing these interactions by a three-dimensional structure. This structure is at the same time flexible enough to allow for diffusion of solvent and analytes into and out of the network. This paper reviews advances in molecular recognition systems, and outlines methods of making molecularly imprinted polymer systems that can recognize large molecular weight analytes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Polymer Science - Volume 33, Issue 3, March 2008, Pages 271-288
Journal: Progress in Polymer Science - Volume 33, Issue 3, March 2008, Pages 271-288
نویسندگان
Nicole M. Bergmann, Nicholas A. Peppas,