کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5209011 | 1503019 | 2007 | 11 صفحه PDF | دانلود رایگان |
This chapter focuses on the synthesis and applications of covalent conjugates of proteins and stimuli-responsive or “smart” polymers. Smart polymer-drug conjugates are included only when the drug is a protein. The conjugation of biotinylated smart polymers to streptavidin is included, as is the use of streptavidin to link a biotinylated protein and a biotinylated smart polymer. Proteins that are conjugated with poly(ethylene glycol) (PEG), or “PEGylated” proteins, are not included in this chapter since PEG is not utilized as a smart polymer in such conjugates. Smart polymer-protein conjugates immobilized on solid surfaces or within hydrogels are also not included, unless they represent the “phase-separated state” of the reversible soluble-insoluble phases of the conjugate.
Journal: Progress in Polymer Science - Volume 32, Issues 8â9, AugustâSeptember 2007, Pages 922-932