کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5209313 | 1503045 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Silk fibroin films for potential applications in controlled release
ترجمه فارسی عنوان
فیلم های فیبرین ابریشم برای کاربردهای بالقوه در انتشار کنترل شده
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کلمات کلیدی
فیلم فیبرین ابریشم، نفوذپذیری، نفوذپذیری، انتشار کنترل شده، تحویل مواد مخدر،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Silk fibroin extracted from Bombyx mori cocoon was processed into regenerated films and examined for potential application in controlled drug release. Instead of using dialysis process, the present study proposed a novel convenient method to remove LiBr from fibroin aqueous solution during film preparation process. The prepared fibroin films were characterized by FTIR and SEM, showing that the films were dense, homogeneous, and partially crystalized. The biocompatibility of fibroin films was initially evaluated by the adsorption of BSA. It was shown that at 10Â mg/mL of BSA concentration, the BSA sorption reached 0.045Â mg/cm2, which is indicative of good blood compatibility and biocompatibility of the fibroin. Further, the permeability and diffusivity of four model drugs in the fibroin films were investigated, and they were found to be on the same orders of magnitudes as many other controlled release materials, indicating that the naturally occurring fibroin is a good candidate material for uses in controlled release. The mass transport through the fibroin film pertaining to controlled drug release was also studied.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 116, July 2017, Pages 57-68
Journal: Reactive and Functional Polymers - Volume 116, July 2017, Pages 57-68
نویسندگان
Yifeng Huang, Kevin Bailey, Sai Wang, Xianshe Feng,