کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5209386 | 1503047 | 2017 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monolithic polydimethylsiloxane-modified silica composites prepared by a low-temperature sol-gel micromolding technique for controlled drug release
ترجمه فارسی عنوان
کامپوزیت سیلیکای اصلاح شده پلی متیل سیلکسان یکپارچه توسط تکنیک میکرومولتیک با روش سل ژل کم برای تولید داروهای کنترل شده
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Sol-gel derived multi-component silica composites are widely accepted as smart materials in orthopedic surgery as bone fillers and bioactive skeleton drug delivery systems. This paper discusses the effect of hydroxy-terminated polydimethylsiloxane (PDMS) (10, 20, 30 and 40% (w/w)) on the physicochemical properties of low temperature sol-gel processed polydimethylsiloxane/calcium phosphate/silica (PDMS-modified CaP/SiO2) composites. The micromolding technique was employed to obtain PDMS-modified CaP/SiO2 composites-monolithic granule-type formulations. The effectiveness of PDMS-modified CaP/SiO2 granules as potential skeleton drug delivery systems was studied in vitro using Rhodamine B (ROD) as a model for highly water-soluble molecules. Results indicated that the composites with PDMS contents at 20 and 30% (w/w) showed similar mechanical properties to those of human cancellous bones. The content of PDMS had a significant effect on the release of ROD. These results showed that PDMS-modified CaP/SiO2 granules with 20 and 30% (w/w) PDMS could provide the zero-order release profile of highly water-soluble molecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 114, May 2017, Pages 136-145
Journal: Reactive and Functional Polymers - Volume 114, May 2017, Pages 136-145
نویسندگان
Magdalena Prokopowicz, Adrian Szewczyk, RafaÅ Åunio, WiesÅaw Sawicki,