کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5209521 | 1503054 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, self-assembly and pH sensitivity of PDEAEMA-PEG-PDEAEMA triblock copolymer micelles for drug delivery
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, well-defined double-hydrophilic triblock copolymers, consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(N,N-diethylamino-2-ethylmethacrylate) (PDEAEMA), were synthesized and characterized. The molecular weights of the copolymers were controllable. In the basic environments, the copolymers can self-assemble into the PDEAEMA core and PEG corona micelles in aqueous solution with an average size of 40-180 nm. The low critical micelle concentration (CMC, about 10â 3 mg mLâ 1) of copolymers investigated in pH 7.4 aqueous solution confirmed the adequate thermodynamic stability of their self-assembly. As shown in the cytotoxicity assay, the copolymers have good biocompatibility. Doxorubicin (DOX) was encapsulated into the triblock copolymer micelles. The drug loading efficiency and entrapment efficiency values of DOX-loaded micelles reached 8.14% and 88.6%, respectively. The DOX release of the drug-loaded micelles depends on the pH values. These phenomena indicated that the double-hydrophilic PDEAEMA-PEG-PDEAEMA triblock copolymers have a potential application in the drug delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 107, October 2016, Pages 1-10
Journal: Reactive and Functional Polymers - Volume 107, October 2016, Pages 1-10
نویسندگان
Guiyou Wang, Lingmei Zhang,