کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5209696 1503063 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Covalent attachment of an influenza hemagglutinin-derived peptide to urethane-based cationic polymers affects their transfection efficiency in DNA delivery and their course in cell entry
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Covalent attachment of an influenza hemagglutinin-derived peptide to urethane-based cationic polymers affects their transfection efficiency in DNA delivery and their course in cell entry
چکیده انگلیسی
Moreover, the results of the present study demonstrated that the effectiveness of PU-PA-1-HAP in DNA delivery is due to the HAP conjugation, which not only helps the formed complexes to escape from endolysosomes, but also opens an alternative pathway (via clathrin as opposed to via caveolae) in transfection. Therefore, the increased capability of the complexes to gain cellular entry causes their increased transfection efficiency. In contrast, PU without HAP (i.e. PU-PA-1) can only deliver DNA into cells through the caveolae-mediated pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 98, January 2016, Pages 9-16
نویسندگان
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