کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5209699 1503063 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hybrid drug carriers with temperature-controlled on-off release: A simple and reliable synthesis of PNIPAM-functionalized mesoporous silica nanoparticles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Hybrid drug carriers with temperature-controlled on-off release: A simple and reliable synthesis of PNIPAM-functionalized mesoporous silica nanoparticles
چکیده انگلیسی

MCM-41-like mesoporous silica nanoparticles (MSNs) grafted with a thermoresponsive copolymer of N-isopropylacrylamide were synthesized, fully characterized and tested to assess their efficiency as drug delivery systems. The hybrid nanoparticles were prepared by carrying out the optimized copolymer synthesis within the mesopores of MSNs after infiltration of monomers and initiator. Polymerization and grafting of the thermoresponsive copolymer occurred simultaneously by exploiting the reactive sites of the 3-methacryloxypropyltrimethoxysilane comonomer which carries a polymerizable group and alkoxysilane groups prone to condensation with surface silanols on silica. The grafted copolymer through its coil-to-globule transition acts as a gatekeeper for the temperature-controlled release of ibuprofen molecules loaded inside the pores. Significant difference in the quantitative release of ibuprofen was observed at 25 and 40 °C, which are below and above the lower critical solution temperature of the thermoresponsive copolymer. Importantly, the ordered mesoporous structure of the MSNs remained intact in all synthetic steps, loading of drug and during the in vitro release tests.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 98, January 2016, Pages 31-37
نویسندگان
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