کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5209844 | 1503077 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fabrication of composition-graded collagen/chitosan-polylactide scaffolds with gradient architecture and properties
ترجمه فارسی عنوان
تهیه داربست کلاژن / کیتوزان-پلییلکتیسی ترکیب با درجه بندی با معماری و خواص گرادیان
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کلمات کلیدی
کلاژن / کیتوزانا کامپوزیت پلی اتیلن، داربست طبقه بندی شده ساختار گرادیان و اموال، تکنیک پردازش ترکیبی ماتریکس خارج سلولی غضروف مفصلی،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Chitosan-polylactide (CH-PLA) copolymers with various polylactide percentages changing from around 14 to 40Â wt% were synthesized. CH-PLAs were then blended with type-II collagen to fabricate layered collagen/CH-PLA scaffolds that are potentially suitable for the applications in articular cartilage repair. Based on combinatorial processing techniques involving layer-superposition, thermal melting and freeze-drying, two types of stratified collagen/CH-PLA scaffolds were built. The content of collagen inside the scaffolds altered from the top layer to the bottom layer in a trend contrary to that of chitosan. One of them was fabricated using tripolyphosphate (TPP) as a single crosslinker and another type of scaffold was constructed via a dual-crosslinking pathway using TPP and genipin as two crosslinkers in a designated order. These collagen/CH-PLA scaffolds were found to have graded average pore-size and porosity, gradient swelling index and layer-dependent compressive modulus. The resulting scaffolds were thus partially similar to the articular cartilage extracellular matrix in composition, structure and property. In vitro cell culture on some optimized collagen/CH-PLA scaffolds for a period of time up to 3Â weeks showed that the scaffolds were able to well support the growth of the seeded cells, suggesting that these collagen/CH-PLA scaffolds have promising potential for articular cartilage repair.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 83, October 2014, Pages 98-106
Journal: Reactive and Functional Polymers - Volume 83, October 2014, Pages 98-106
نویسندگان
Dengke Yin, Hua Wu, Chaoxu Liu, Jun Zhang, Ting Zhou, Jingjing Wu, Ying Wan,