کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5210079 1382873 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and structure-property relationship of polyester-urethanes and their evaluation for the regeneration of contractile tissues
ترجمه فارسی عنوان
سنتز و رابطه ساختار و اموال پلی استر اوریتان و ارزیابی آنها برای بازسازی بافت های انقباضی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
The structure-property relationship of degradable polyurethanes from non toxic building blocks was studied by synthesising four different biodegradable poly(ester urethanes) from poly(ε-caprolactone) (PCL) diol, 1,4-diisocyanatobutane and different chain extenders. For instance, the chain extenders were an amino acid derivative diamine, an amino acid derivative diol, a cyclic diol and a custom made diamine, containing an enzymatically degradable peptide (Ala-Ala sequence). Physicochemical and morphological characterisation (SEC, DSC, DMA, AFM) was performed, showing the influence of the chain extender on the polyurethane properties. A correlation between surface domain morphologies and thermal properties was highlighted and a relationship between the biological response and surface morphologies was observed. Collecting mechanical characterisation and myoblast cell culture results together, the polyurethane synthesised with the amino acid derivative diamine resulted the most promising candidate for fabricating scaffolds supporting the regeneration of muscle tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 73, Issue 10, October 2013, Pages 1366-1376
نویسندگان
, , , , , , , , ,