کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210268 | 1382883 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and self-assembly of a dual-functional copolymer for cancer therapy
ترجمه فارسی عنوان
آماده سازی و خودآموزی یک کوپلیمر دو طرفه برای درمان سرطان
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
The pH-responsive amphiphilic copolymer poly(SDMA-co-OEGMA) (PSO) was prepared from the pH-sensitive hydrophobic monomer 2-styryl-1,3-dioxan-5-yl methacrylate (SDMA) and the hydrophilic monomer oligo(ethylene glycol) methyl ether methacrylate (OEGMA) by radical polymerization. Polymeric aggregates with about 130Â nm diameter were obtained by the self-assembly of PSO in neutral aqueous solution. The critical aggregation concentration of the copolymer was determined to be 6.5Â mg/L (1.2Â ÃÂ 10â7Â M). Cinnamic aldehyde (CA) small molecules are broken away from PSO side chains after the hydrolysis of acid-labile cyclic acetal in cultured A375 human melanoma cells and further suppress the proliferation of this kind of tumor cells. Furthermore, the PSO aggregate was demonstrated to be a drug carrier for encapsulating Nile Red as model drug in in vitro testing. Based on the pH-responsive characteristic, the Nile Red molecules loaded in self-assembly process could be released from the aggregate inside cultured B16 mouse melanoma cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 73, Issue 1, January 2013, Pages 89-96
Journal: Reactive and Functional Polymers - Volume 73, Issue 1, January 2013, Pages 89-96
نویسندگان
Xiuxiu Qi, Najun Li, Hongwei Gu, Qingfeng Xu, Hua Li, Jianfeng Ge, Jianmei Lu,