کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210324 | 1382886 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel triple-responsive poly(3-acrylamidephenylboronic acid-co-2-(dimethylamino) ethyl methacrylate)/(β-cyclodextrin-epichlorohydrin)hydrogels: Synthesis and controlled drug delivery
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this work, a novel triple-responsive poly(3-acrylamidephenylboronic acid-co-(2-dimethylamino) ethyl methacrylate)/(β-cyclodextrin-epichlorohydrin) (P(AAPBA-co-DMAEMA)/(β-CD-EPI)) semi-interpenetrating (semi-IPN) hydrogel was prepared. The structures of the resultant hydrogels were studied by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The results from swelling studies reveal that the equilibrium swelling ratios (ESRs) of P(AAPBA-co-DMAEMA)/(β-CD-EPI) semi-IPN hydrogels are significantly affected by pH, temperature, ionic strength and glucose concentration of the swelling media. Release studies that used aminophylline and ibuprofen as hydrophilic and hydrophobic model drug, respectively, show that the drug loading ratio of hydrophobic drugs is apparently higher than that of hydrophilic drugs. It is also depicted that the release behaviors of model drug from the P(AAPBA-co-DMAEMA)/(β-CD-EPI) semi-IPN hydrogels depend on pH, glucose concentration and solvent type of release medium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 71, Issue 6, June 2011, Pages 666-673
Journal: Reactive and Functional Polymers - Volume 71, Issue 6, June 2011, Pages 666-673
نویسندگان
Yinjuan Huang, Mingzhu Liu, Lu Wang, Chunmei Gao, Shanshan Xi,