کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210373 | 1382890 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Using a bifunctional polymer for the functionalization of Fe3O4 nanoparticles
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Using a bifunctional polymer for the functionalization of Fe3O4 nanoparticles Using a bifunctional polymer for the functionalization of Fe3O4 nanoparticles](/preview/png/5210373.png)
چکیده انگلیسی
A bifunctional maleimido-tetra(ethylene glycol)-poly(glycerol monoacrylate) (MAL-TEG-PGA) polymer was synthesized and used as a linker to couple functional biomolecules to iron oxide nanoparticles. The cell-penetrating peptide Tat was chosen as a model ligand and successfully conjugated to the surface of Fe3O4 nanoparticles using MAL-TEG-PGA. The Tat-conjugated Fe3O4 nanoparticles can be prepared simply by applying the linker to the iron oxide nanoparticles and then coupling the Tat peptide to the maleimide terminus or by coating the nanoparticles with a pre-coupled linker. Cell-uptake studies demonstrated that the Tat peptide was an efficient functional biomolecule to translocate iron oxide nanoparticles into the cell nucleus. Tat-conjugated nanoparticles thus prepared may be useful for drug or gene delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 72, Issue 3, March 2012, Pages 198-205
Journal: Reactive and Functional Polymers - Volume 72, Issue 3, March 2012, Pages 198-205
نویسندگان
Quan Zhang, Liang Luan, Siliang Feng, Husheng Yan, Keliang Liu,