کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5210469 1382895 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Application of two morphologically different fibrillar and filamentous insulin amyloids as a biomaterial for cell culture surfaces
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Application of two morphologically different fibrillar and filamentous insulin amyloids as a biomaterial for cell culture surfaces
چکیده انگلیسی
Synthetic biomaterials, such as polymers and self-assembling polypeptides have been developed for cell culture. The self-assembly of misfolded proteins, which is so-called 'amyloid', has also been demonstrated to work as a cell adhesive biomaterial. In this study, we demonstrated that two morphologically different insulin amyloids, fibrils and filaments, can be used as biomaterials for cell culture. We previously showed that the cytotoxicity of insulin filaments is markedly lower than that of fibrils. Both types of insulin amyloid-coated dishes showed higher cell adhesion and cell proliferation ability compared to non-coated dishes. Interestingly, insulin filaments showed higher cell adhesion and cell proliferation ability compared to insulin fibrils. These results strongly suggest that insulin amyloids, and insulin filaments in particular, can be used as a biomaterial for cell culture surfaces.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 71, Issue 3, March 2011, Pages 324-328
نویسندگان
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