کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210501 | 1382897 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Star polymers with random number of temperature sensitive arms and crosslinked poly(EGDMA)-core and their application to drug delivery
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A simple methodology is described for the preparation of temperature sensitive star polymers with random number of arms and crosslinked core. In the first step, well defined, monodisperse poly(N-isopropylacrylamide) PNIPAAm polymers were prepared by reversible addition-fragmentation chain transfer polymerization (RAFT-polymerization) by using 4-cyanopentanoic acid dithiobenzoate as chain transfer agent (CTA). In the second step, the PNIPAAm polymers were used as macro-CTA's for copolymerization with ethylene glycol dimethacrylate (EGDMA) by the RAFT-technique. Adjusting the macro-CTA to EGDMA ratio, nanometric star polymers with small or big core could be prepared as revealed by gel permeation chromatography (GPC), dynamic light scattering (DLS) and viscometry. The same methodology was applied for the preparation of star polymers with poly(NIPAAm)-b-poly(hexyl acrylate) arms. The so prepared temperature sensitive multiarm materials are a stable alternative to polymeric micelles as nano-carriers for drug-delivery applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 71, Issue 11, November 2011, Pages 1077-1088
Journal: Reactive and Functional Polymers - Volume 71, Issue 11, November 2011, Pages 1077-1088
نویسندگان
Jesús Alvarez-Sánchez, Angel Licea-ClaverÃe, José M. Cornejo-Bravo, Curt W. Frank,