کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210641 | 1382907 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ring-opening metathesis polymerization of steroid-conjugated norbornenes and gradual release of estrone from a polymer film
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Steroids (estrone, estradiol, ursodeoxycholic acid, chenodeoxycholic acid, cortisone, prednisone, and dexamethasone) were reacted with either 5-norbornene-2-carboxylic acid chloride or 5-norbornene-2-methanol to form new norbornene derivatives with bioactive and sterically demanding steroid residues bound with an ester linkage. These norbornene-based monomers were polymerized by a ring-opening metathesis polymerization initiated by a ruthenium-carbene complex (Grubbs catalyst) or a ruthenium-vinylidene complex. With a few exceptions, the polymers were soluble in THF, and casting the solution produced films. Solid-state hydrolysis of the estrone-conjugated polymer film showed a slow but steady release of estrone under mild conditions (pH 5.5 or 3.0 at 37 °C).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 70, Issue 9, September 2010, Pages 563-571
Journal: Reactive and Functional Polymers - Volume 70, Issue 9, September 2010, Pages 563-571
نویسندگان
Shoujiro Ogawa, Shigenaga Takano, Hiroki Fujimori, Toshihiro Itoh, Shojiro Kaita, Takashi Iida, Yasuo Wakatsuki,