کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5210650 1382907 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and in vitro degradation of poly(ester-anhydride)s based on succinic acid and 1,6-bis-p-carboxyphenoxyhexane
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, characterization and in vitro degradation of poly(ester-anhydride)s based on succinic acid and 1,6-bis-p-carboxyphenoxyhexane
چکیده انگلیسی

This paper describes synthesis and characteristics of functional poly(ester-anhydride)s bearing allyl pendant groups. The polymers were obtained by polycondensation of 1,6-bis-p-carboxyphenoxyhexane (CPH) and oligo(3-allyloxy-1,2-propylene succinate) terminated with carboxyl groups (OSAGE). The carboxyl groups in OSAGE and in CPH were converted to mixed anhydride groups by acetylation with acetic anhydride. After that, prepolymers thus obtained were condensed in vacuum to yield poly(ester-anhydride)s. The structure of copolymers was confirmed by NMR spectroscopy. Influence of molecular weight of OSAGE as well as of the CPH and OSAGE content on selected properties of poly(ester-anhydride)s was examined. Poly(ester-anhydride)s were subjected to hydrolytic degradation at 37 °C, in aqueous phosphate buffer solution of pH 7.41 (PBS). The course of degradation was monitored by determination of weight loss of samples and 1H NMR. Fracture surfaces of samples during degradation were examined by scanning electron microscopy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 70, Issue 9, September 2010, Pages 630-638
نویسندگان
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