کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5211232 | 1382941 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spacer-modified crosslinked copolymer beads for the solid phase synthesis of an amide
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Spacer-modified crosslinked copolymer beads for the solid phase synthesis of an amide Spacer-modified crosslinked copolymer beads for the solid phase synthesis of an amide](/preview/png/5211232.png)
چکیده انگلیسی
The goal of this research was to synthesize an amide using the reaction of a polymer-supported active ester with a primary amine. A new type of the polymer support for an active ester was prepared from poly(Ï-bromobutylstyrene-co-divinylbenzene) beads (1). Bromine atoms in 1 were replaced by mercapto groups upon treatment with thiourea and subsequent alkaline hydrolysis. Following this, N-hydroxymaleimide was reacted with the polymer (3). This reaction introduced N-hydroxysuccinimide moieties into the polymer beads via Michael addition, yielding a resin (4). Resin 4 was reacted with a model carboxylic acid in the presence of a water-soluble esterification reagent (WSC). This yielded resin (5), which contained polymer-bound active ester groups. Reaction of 5 with a primary amine gave the objective amide. Resulting amides had a higher purity than those prepared by solid phase synthesis using the corresponding polymer support, which was derived with poly(chloromethylstyrene-co-divinylbenzene) beads and a traditional liquid phase synthesis. Resin 5, after use in the amide synthesis, was regenerated into the active ester form for the repeated use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 68, Issue 7, July 2008, Pages 1127-1131
Journal: Reactive and Functional Polymers - Volume 68, Issue 7, July 2008, Pages 1127-1131
نویسندگان
Kazumi Nagata, Tomomi Fukunaga, Shota Kato, Akinori Jyo,