A review: Non-cross-linked polystyrene bound reagents, catalysts and syntheses

Non-cross-linked polystyrene (NCPS), as a type of soluble polymer having remarkable properties, has attracted more and more attention. Many organic synthetic applications based on NCPS have been shown great success. NCPS is easily functionalized and can be used as supports in organic synthesis. Comparing to classical liquid-phase synthesis, their advantages involve simplified isolation, cycling procedures and increasing stereoselectivity. This review reported the recent developments using NCPS bound reagents focusing on three aspects: (1) NCPS-bound reagents, (2) NCPS-bound catalysts and (3) NCPS-bound syntheses.