کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5211775 1382979 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liquid-phase parallel synthesis of di(aryloxyacetyl)thiosemicarbazides on poly(ethylene glycol)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Liquid-phase parallel synthesis of di(aryloxyacetyl)thiosemicarbazides on poly(ethylene glycol)
چکیده انگلیسی

An efficient poly(ethylene glycol) (PEG)-supported liquid-phase parallel approach to di(aryloxyacetyl)thiosemicarbazides is described. PEG-bound phenol reacted with chloroacetic acid to afford PEG-bound phenyloxyacetic acid, which was readily converted into corresponding phenyloxyacetyl chloride. Subsequent nucleophilic substitution with ammonium thiocyanate followed by addition of aryloxyacetic acid hydrazides gave PEG-bound di(aryloxyacetyl)thiosemi-carbazides, which were easily cleaved to give the resulting library of 1-aryloxyacetyl-4-(4′-methoxylcarbonylphenyloxyacetyl)thiosemicarbazides in good to high yield and high purity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 66, Issue 5, May 2006, Pages 527-530
نویسندگان
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