کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5211815 | 1382988 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and lipoprotein sorption properties of porous chitosan beads grafted with poly(acrylic acid)
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and lipoprotein sorption properties of porous chitosan beads grafted with poly(acrylic acid) Synthesis and lipoprotein sorption properties of porous chitosan beads grafted with poly(acrylic acid)](/preview/png/5211815.png)
چکیده انگلیسی
Porous chitosan beads bearing poly(acrylic acid) (PAA) were prepared, and then tested as hemoperfusion adsorbents for selective removal of low density lipoprotein (LDL) in plasma. Macroporous chitosan beads were formed through phase inversion technique and cross-linked with ethyleneglycol diglycidylether (EGDE). Heterogeneous graft copolymerization of acrylic acid (AA) onto the cross-linked beads was carried out with ammonium persulfate (APS) as an initiator. FTIR spectral analyses confirmed the successful grafting, and environmental scanning electronic microscopy (ESEM) observation showed the decrease of the pore size across the beads with increasing PAA grafting percentage. The effect of reaction conditions, such as temperature, time and the concentrations of the monomer and the initiator, on PAA grafting percentage and efficiency was investigated in detail. The results revealed that the amount of PAA contained in the resultant copolymer beads could be readily controlled by adjusting the reaction variables. The plasma lipoprotein sorption tests showed that the introduction of PAA onto the cross-linked chitosan beads could greatly improve both their LDL binding capacity and selectivity. The lipoprotein sorption performance exhibited direct dependence on the PAA grafting percentage. Therefore, the properly prepared PAA-grafted beads might have potential application in selective removal of LDL by hemoperfusion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 66, Issue 2, February 2006, Pages 239-246
Journal: Reactive and Functional Polymers - Volume 66, Issue 2, February 2006, Pages 239-246
نویسندگان
Guoqi Fu, Haiyan Li, Haofeng Yu, Li Liu, Zhi Yuan, Binglin He,