The Chan-Evans-Lam N-arylation of phosphonic/phosphinic amides

A stoichiometric copper(II)-mediated arylation protocol of phosphinamides and phosphonamides was herein demonstrated. Various unreported N-aryl phosphinamides and phosphonamides were successfully prepared through Chan-Evans-Lam reaction with high efficiency (up to 88% yields) and good functional groups tolerance (30 examples) in the absence of any ligands or co-catalysts.

A general and efficient arylation protocol of phosphinamides and phosphonamides was herein demonstrated. And various unreported N-aryl phosphinamides and phosphonamides were successfully prepared through the Chan-Evans-Lam reaction with high efficiency (up to 88% yields) and good functional groups tolerance (30 examples). The stoichiometric copper(II)-mediated transformation required for no organic ligands or co-catalysts.153