CuI-catalyzed Sonogashira reaction for the efficient synthesis of 1H-imidazo[2,1-a]isoquinoline derivatives

The Sonogashira reaction first, and then intra-molecular hydroamination of alkyne catalyzed by CuI/o-phen was proved to be an efficient method for the synthesis of imidazo[2,1-a]isoquinoline derivatives in the presence of Cs2CO3.157