کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5212504 1383119 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Water-acetic acid mediated chemoselective synthesis of pyrazolines via multimolecular domino reactions of enaminones and sulfonyl hydrazines
ترجمه فارسی عنوان
اسید آب استیک با استفاده از سنتز شیمیایی مولکولی پریآزولین ها از طریق واکنش های دومینو چند مولکولی پروتئین ها و سولفونیل هیدرازین ها
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Water-AcOH mediated domino reactions of enaminones and sulfonyl hydrazines.
• Unprecedented chemoselectivity to pyrazolines instead of pyrazoles.
• Novel pyrazoline products containing sulfonyl hydrazine side chain.
• No chromatographic purification.

The domino reactions between enaminones and sulfonyl hydrazines enabling novel synthesis of pyrazoline have been achieved by employing water as reaction medium and acetic acid as cheap and green additive are reported. Two new CN and one new CN bonds have been constructed during the formation of these pyrazoline scaffolds. Unlike the conventional formation of pyrazoles in the organic solvent mediated reactions of enaminones and hydrazines, the present reactions providing pyrazolines disclose new transformation pattern of enaminones by employing water as medium.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 73, Issue 16, 20 April 2017, Pages 2323–2328