Study on the propylphosphonic anhydride (T3P®) mediated Ugi-type three-component reaction. Efficient synthesis of an α-amino amide library

In the present work, a mild and simple synthesis of α-amino amides has been developed via the one-pot three-component ABC type Ugi reaction of a wide variety of aromatic aldehydes and primary aromatic amines, and two different aliphatic isocyanides. The reactions took place rapidly at room temperature in the presence of 1-propanephosphonic acid cyclic anhydride (T3P®), rendering possible the highly efficient preparation of an α-amino amide library in medium to excellent yields. This study represents the first case in which T3P® has been used in the Ugi reaction.