کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5212863 1383136 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Base-catalyzed hydrogen–deuterium exchange and dehalogenation reactions of 1,2,3-triazole derivatives
ترجمه فارسی عنوان
مبادله دایتریم و واکنش های دی هالیزی واکنش مشتقات 1،2،3-تریازول هیدروژن کاتالیز شده پایه
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

An efficient and convenient synthesis of deuterium-labeled 1,2,3-triazoles using base-catalysis with DMSO-d6 as the deuterium source was developed. A series of deuterated 1,2,3-triazoles bearing various substituents were produced by hydrogen–deuterium exchange reactions of pre-synthesized original 1,2,3-triazoles, giving high level of deuteration and high yields. The catalytic system was successfully extended to the dehalogenation and halogen–deuterium exchange procedures of iodo-functionalized 1,2,3-triazolyl derivatives. This study forms a promising basis for the future development of 1,2,3-triazolyl-containing organic derivatives, polymeric materials and biomedical molecules.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 72, Issue 41, 13 October 2016, Pages 6375–6379