The first synthesis of Crucigasterin 277-a polyunsaturated C-18 amino alcohol from the Mediterranean tunicate Pseudomonas crucigaster

Starting from eicosapentaenoic acid (EPA) and d-alanine, the first synthesis of (2R, 3S)-crucigasterin 277, a polyunsaturated C-18 amino alcohol from the Mediterranean tunicate, Pseudodistoma crucigaster, is described.