Miscellaneous meroterpenoids from Ganoderma applanatum

Twenty-six new meroterpenoids, applanatumols C-Z (1–24), Z1 (25) and Z2 (26), and three new alkaloids, ganoapplanatumines A (27), B (28) and epi-ganoapplanatumine B (29), were isolated from the fruiting bodies of Ganoderma applanatum. With exception of 18 and 25, all the other compounds are racemates, Chiral HPLC separation afforded their respective enantiomers. The structures of these isolates including their absolute configurations were assigned by spectroscopic and computational methods. In particular, the structures of 1, 3 and 12 were confirmed by single crystal X-ray diffraction data. Biological activities of all the isolates against COX-1 and COX-2 were evaluated, compound 1a was found to have COX-2 inhibitory effect with IC50 value of 25.5 μM.

Figure optionsDownload as PowerPoint slide