Synthesis of novel imidazo[1,2-a]pyridine-4-hydroxy-2H-coumarins by Groebke–Blackburn–Bienaymé multicomponent reaction as potential NS5B inhibitors

A new series of imidazo[1,2-a]pyridine-coumarin hybrid has been developed by combining two biologically active pharmacophores coumarin and imidazo[1,2-a]pyridine following a Groebke–Blackburn–Bienaymé multicomponent reaction (MCR). Molecular docking studies of these novel compounds with nonstructural protein 5B (NS5B) exhibited promising binding interactions by forming hydrogen bond at Ser476, Trp528, Arg422 and Arg501, directly and hydrophobic contacts with Leu419, Ile482, Leu497, Leu489, Met423, Leu474 and His475, which are potentially useful for a new scaffold discovery.

Figure optionsDownload as PowerPoint slide