Revisiting the 7,8-cis-vitamin D3 derivatives: synthesis, evaluating the biological activity, and study of the binding configuration

Vitamin D twistable?: 7,8-cis-19-norvitamin D3 with a 14-epi-19-nortachysterol structure is stable with keeping tiny receptor binding affinity, and 7,8-cis-vitamin D3 prefers to take the natural 1α,25-dihydroxyvitamin D3 skeleton.