کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5214044 | 1383182 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, characterization and cytotoxicity of new piplartine dimers
ترجمه فارسی عنوان
سنتز، خصوصیات و سیتوتوکسیسیتهای جدید دیورهای پیلپراتین
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Several head-to-head and head-to-tail dimers of piplartine (1a) were prepared, and the configurations of the resulting truxillic and truxinic acid derivatives were established by a combination of NMR experiments and single-crystal X-ray analysis. Their cytotoxic activity was screened in photometric sulforhodamine B assays. All of these dimers showed a decreased cytotoxicity compared to 1a except for the β-truxinic acid derivative 3a. For this unprecedented head-to-head dimer high cytotoxic activity was established against several human tumor cell lines, and IC50 values as low as 1.1 μM were found.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 72, Issue 11, 17 March 2016, Pages 1447–1454
Journal: Tetrahedron - Volume 72, Issue 11, 17 March 2016, Pages 1447–1454