Iodine-catalyzed aerobic oxidative formal [4+2] annulation for the construction of polyfunctionalized pyridines

An iodine-catalyzed aerobic oxidative formal [4+2] annulation for the construction of polyfunctionalized pyridines in one step has been developed through the green reaction system of catalytic amounts of molecular iodine and amine in combination with oxygen. Various ketones and aldehydes were able to react with different chalcones and β, γ-unsaturated α-ketoesters through this reaction strategy. Synthetically, this iodine catalytic system could be scaled up with good efficiency.

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