کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5214188 1383188 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
l-Proline-catalyzed multicomponent synthesis of 3-indole derivatives
ترجمه فارسی عنوان
ال-پرولین کاتالیز شده چندتایی سنتز مشتقات 3-اندول
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A green one-pot multicomponent reaction for the synthesis of 3-indole derivatives was developed via l-proline-catalyzed condensation between indoles, aldehydes, and malononitrile. The process was carried out in ethanol at room temperature, and the desired products were obtained in good to excellent yields of up to 98%. Pyrrole as the nucleophile and 2,2,2-trifluoroacetophenone as the electrophile can also work in this transformation. The salient features of this protocol were environmental friendliness, simplicity of the procedure, ready accessibility of the catalyst, high yield, and mild reaction conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 71, Issue 49, 9 December 2015, Pages 9299-9306
نویسندگان
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