DCDMH-promoted synthesis of thiophosphates by coupling of H-phosphonates with thiols

DCDMH-mediated phosphorylation of versatile thiols with H-phosphonates for the preparation of synthetically and biologically important thiophosphates was demonstrated. Without metal catalysts and other additives, phosphorylation occurred to give the desired products with good to excellent yields within 10 min at ambient temperature in the air.

Figure optionsDownload as PowerPoint slide