کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5214297 1383192 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Total synthesis of splenocin B, a potent inhibitor of the pro-inflammatory cytokine from marine-derived Streptomyces sp.
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Total synthesis of splenocin B, a potent inhibitor of the pro-inflammatory cytokine from marine-derived Streptomyces sp.
چکیده انگلیسی

The first total synthesis of splenocin B (1), a new potent anti-inflammatory antimycin-class antibiotic, has been described. The synthesis of 1 has been accomplished in 8 linear steps, starting from commercially available N-Boc-L-threonine benzyl ester 4 and 3,4-dihydroxypentanoic acid derivative 2. Kita–Trost lactonization via an ethoxyvinyl ester intermediate was utilized for the construction of the 9-membered dilactone core.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 71, Issue 52, 30 December 2015, Pages 9626–9629