A FRET-based ratiometric fluorescent probe for visualizing H2S in lysosomes

Hydrogen sulfide (H2S) is an endogenously produced gaseous signaling molecule with multiple biological functions. In order to detect the biological H2S, here a new FRET-based ratiomatric fluorescent probe was designed and synthesized for visualization of H2S in lysosomes. The probe displays good solubility, a marked yellow to blue emission color change in response of H2S and high H2S selectivity. Moreover, the probe could be used to detect of H2S in lysosomes with good biocompatibility.

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