Multicomponent synthesis of novel coelenterazine derivatives substituted at the C-3 position

Three novel coelenterazine derivatives substituted at the C-3 position were synthesized through a multicomponent strategy based on Groebke–Blackburn–Bienaymé reaction without using protecting groups. An efficient one-pot tert-butyl group cleavage from an aminoimidazopirazine and the first example of direct diazoimidazole derivative hydrogen abstraction in acidified water (traditional Sandmeyer hydroxylation conditions) were described.

Figure optionsDownload high-quality image (128 K)Download as PowerPoint slide