کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5214735 | 1383207 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The first enantioselective total synthesis of lantalucratin C and determination of its absolute configuration
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The first enantioselective total synthesis of lantalucratin C and determination of its absolute configuration The first enantioselective total synthesis of lantalucratin C and determination of its absolute configuration](/preview/png/5214735.png)
چکیده انگلیسی
Described here is the first enantioselective total synthesis of lantalucratin C, which was isolated from the rainforest plant Lantana involucrata, and which possesses anti-tumor activity. The OH group on the aromatic ring was systematically introduced by an appropriate management of the OH protecting groups. The alkyl side chain connected to a chiral carbon center was incorporated by directed ortho-lithiation of naphthalenes followed by asymmetric epoxidation. The furano-1,2-naphthoquinone skeleton was constructed from 3-hydroxyalkylnaphthalene by CAN-mediated oxidative cyclization. The absolute stereochemistry at the C2 carbon was assigned the R-configuration by the Kusumi-Mosher method.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 71, Issue 38, 23 September 2015, Pages 6672-6680
Journal: Tetrahedron - Volume 71, Issue 38, 23 September 2015, Pages 6672-6680
نویسندگان
Tokutaro Ogata, Manami Tanaka, Momoe Ishigaki, Maki Shimizu, Arisa Nishiuchi, Kiyofumi Inamoto, Tetsutaro Kimachi,