Efficient and stereoselective synthesis of α-hydrazino tetrazoles through a pseudo five-component domino reaction

A concise and efficient route for the diastereoselective synthesis of new and interesting α-hydrazino tetrazoles has been developed through a pseudo five-component domino reaction using the isocyanide-based one-pot multicomponent reaction. The products were obtained by a facile Ugi-azide pseudo five-component reaction of cyclic ketones, hydrazine hydrate, trimethylsilyl azide, and corresponding isocyanides without any catalyst in good yields and with high bond forming efficiency at room temperature.

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