Nickel promoted switchable hydroheteroarylation of cyclodienes via C–H bond activation of heteroarenes

We demonstrated Ni-catalyzed switchable hydroheteroarylation of cyclic dienes via C–H bond activation of heteroarenes. In the presence of an N-heterocyclic carbene (NHC) ligand, hydroheteroarylation of cyclic diene with azole afforded α-alkenyl-azole, forging a Heck-like product without using any external oxidant. Conversely, changing the ligand to PCy3 would switch this reaction manifold to afford the other isomeric β-alkenyl substituted azole.

We demonstrated Ni-catalyzed switchable hydroheteroarylation of cyclic dienes via C–H bond activation of heteroarenes. In the presence of an N-heterocyclic carbene (NHC) ligand, hydroheteroarylation of cyclic diene with azole afforded α-alkenyl-azole, forging a Heck-like product without using any external oxidant. Conversely, changing the ligand to PCy3 would switch this reaction manifold to afford the other isomeric β-alkenyl substituted azole.Figure optionsDownload high-quality image (142 K)Download as PowerPoint slide